Boc-hyp-obzl → Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

Participants

Reaction Steps

To a solution of 10.0 g of the compound obtained in Step 157-1 in EtOAc (49 ml) was added a solution of 4 mol/L hydrochloric acid/EtOAc (39 ml). The solution was stirred at room temperature for one hour. The precipitated crystal was filtered, and the crystal was washed with EtOAc. The title compound in the amount of 6.70 g (colorless solid) was obtained.

Provenance & Evidence