huagongshe.com
HRID1662723

反应详情

EQUATION

反应方程式

HRID 1662723 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1C[C@H](O)C[C@H]1C(=O)OCc1ccccc1
HCID11902907

未命名化合物

结构：CCOC(C)=O.Cl
HCID21866389

未命名化合物

PRODUCTS

生成物

1
结构：Cl.O=C(OCc1ccccc1)[C@@H]1C[C@@H](O)CN1
HCID16212860

Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

C12H16ClNO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a solution of 10.0 g of the compound obtained in Step 157-1 in EtOAc (49 ml) was added a solution of 4 mol/L hydrochloric acid/EtOAc (39 ml). The solution was stirred at room temperature for one hour. The precipitated crystal was filtered, and the crystal was washed with EtOAc. The title compound in the amount of 6.70 g (colorless solid) was obtained.

WORKUP

后处理

  1. filtrationThe precipitated crystal was filtered
  2. washthe crystal was washed with EtOAc