5-chloro-1H-indole-2,3-dione → HCID 67429842, compound

HRID 1662740Notes

Reaction equation

HRID 1662740 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].Br[C:14]1[CH:22]=[CH:21][C:17]([N:18]([CH3:20])[CH3:19])=[CH:16][C:15]=1[O:23][CH3:24]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([C:14]1[CH:22]=[CH:21][C:17]([N:18]([CH3:19])[CH3:20])=[CH:16][C:15]=1[O:23][CH3:24])[OH:12]

Participants

3

Reactant 2

HCID 872035-chloro-1H-indole-2,3-dioneHCID 86625715HCID 86625715, compound

Product 1

HCID 67429842HCID 67429842, compoundYield 42.1%

Procedure

With 1.97 g of 5-chloroisatin and 4.99 g of the compound obtained in Step 194-1 as starting materials, 1.52 g of the title compound (pale yellow amorphous) was obtained by a similar method to Step 21-1.

Sources & evidence

ORD record
ord-b8928500f638439da947cac8d07f04ff
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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