5-chloro-1H-indole-2,3-dione → HCID 67427836, compound

HRID 1662744Notes

Reaction equation

HRID 1662744 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:10]2[O:14][CH2:13][CH2:12][O:11]2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Cl:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[C:19]2=[O:26]>>[Cl:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:25])[C:19]2([C:2]1[CH:3]=[C:4]([CH:10]2[O:14][CH2:13][CH2:12][O:11]2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9])[OH:26]

Participants

3

Reactant 2

HCID 872035-chloro-1H-indole-2,3-dioneHCID 179350472-(3-Bromo-4-methoxyphenyl)-1,3-dioxolane

Product 1

HCID 67427836HCID 67427836, compoundYield 43.8%

Procedure

With 30.0 g of the compound obtained in Step 196-1 and 17.52 g of 5-chloroisatin as starting materials, 15.3 g of the title compound (yellow solid) was obtained by a similar method to Step 21-1.

Sources & evidence

ORD record
ord-a2f1c4ee57b14f49895957514763032b
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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