HRID1662745

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(S(=O)(=O)N2C(=O)C(c3cc(C)ccc3OC)(N3C[C@H](OCC(O)CO)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC(F)(F)F)c1

HCID59867958

未命名化合物

结构：CN(C)C(=O)[C@@H]1C[C@@H](O)CN1.O=C(O)C(F)(F)F

HCID67429482

未命名化合物

结构：COc1ccc(C=O)cc1C1(Cl)C(=O)Nc2ccc(Cl)cc21

HCID86625717

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C=O)cc1C1(N2C[C@H](O)C[C@H]2C(=O)N(C)C)C(=O)Nc2ccc(Cl)cc21

HCID86625716

未命名化合物

PROCEDURE

实验过程

With 26.3 g of the compound obtained in Step 198-1 and (4R)-4-hydroxy-N,N-dimethyl-L-prolinamide trifluoroacetate (35.1 mmol) as starting materials, 12.5 g of a diastereoisomer mixture of the title compound (colorless amorphous) was obtained by a similar method to Step 4-2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-00ac955e659748638112eb533efb2ac7
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030499B2
来源说明: uspto-grants-2011_10

反应 SMILES

Cl[C:2]1([C:13]2[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=2[O:21][CH3:22])[CH:16]=[O:17])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].FC(F)(F)C(O)=O.[OH:30][C@H:31]1[CH2:35][NH:34][C@H:33]([C:36]([N:38]([CH3:40])[CH3:39])=[O:37])[CH2:32]1.ClC1C=C2C(=CC=1)N(S(C1C=CC(OC)=CC=1OC(F)(F)F)(=O)=O)C(=O)C2(N1C[C@H](OCC(O)CO)C[C@H]1C(N(C)C)=O)C1C=C(C)C=CC=1OC>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([N:34]1[CH2:35][C@H:31]([OH:30])[CH2:32][C@H:33]1[C:36]([N:38]([CH3:40])[CH3:39])=[O:37])[C:13]1[CH:14]=[C:15]([CH:16]=[O:17])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]