5-chloro-1H-indole-2,3-dione → HCID 67429103, compound

HRID 1662750Notes

Reaction equation

HRID 1662750 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[CH2:5][O:6][Si:7]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8].[Cl:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24](=[O:29])[C:23]2=[O:30]>>[Si:7]([O:6][CH2:5][C:4]1[CH:14]=[CH:15][C:16]([O:17][CH3:18])=[C:2]([C:23]2([OH:30])[C:22]3[C:26](=[CH:27][CH:28]=[C:20]([Cl:19])[CH:21]=3)[NH:25][C:24]2=[O:29])[CH:3]=1)([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 872035-chloro-1H-indole-2,3-dioneHCID 86625718[(3-Bromo-4-methoxybenzyl)oxy] (tert-butyl) dimethyl silane

Product 1

HCID 67429103HCID 67429103, compoundYield 60.5%

Procedure

With 100 g of the compound obtained in Step 204-2 and 45.8 g of 5-chloroisatin as starting material, 66.2 g of the title compound (opal solid) was obtained by a similar method to Step 21-1.

Sources & evidence

ORD record
ord-628ee5758eb74566828bb887c0e53c69
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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