HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → (4R)-1-(5-chloro-3-{5-[2-(diethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluorome thoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinami de
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | HCID 59867806 | HCID 59867806 | — |
| Product | (4R)-1-(5-chloro-3-{5-[2-(diethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluorome thoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinami de | HCID 59867874 | — |
Reaction Steps
With 500 mg of the compound obtained in Example 219 and diethyl amine (0.16 ml) as starting materials, 180 mg of the title compound (light yellow amorphous) was obtained by a similar method to Example 220.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030499B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-bcb58c5d8cc641bf99e21f2ef8c9fa0d |
| Source note | uspto-grants-2011_10 |