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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1662761Generated: October 31, 2026

Diethylamine → (4R)-1-(5-chloro-3-{5-[2-(diethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluorome thoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinami de

https://huagongshe.com/reaction/1662761

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethylamineHCID 8021—
ReactantHCID 59867806HCID 59867806—
Product(4R)-1-(5-chloro-3-{5-[2-(diethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluorome thoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinami deHCID 59867874—

Reaction Steps

With 500 mg of the compound obtained in Example 219 and diethyl amine (0.16 ml) as starting materials, 180 mg of the title compound (light yellow amorphous) was obtained by a similar method to Example 220.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08030499B2
Source datasetuspto-grants-2011_10
ORD IDord-bcb58c5d8cc641bf99e21f2ef8c9fa0d
Source noteuspto-grants-2011_10