Diethylamine → (4R)-1-(5-chloro-3-{5-[2-(diethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluorome thoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinami de

HRID 1662761Notes

Reaction equation

HRID 1662761 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][C:23]([F:26])([F:25])[F:24])(=[O:13])=[O:12])[C:6](=[O:27])[C:5]2([N:39]1[CH2:48][C@H:47]([OH:49])[CH2:46][C@H:40]1[C:41]([N:43]([CH3:45])[CH3:44])=[O:42])[C:28]1[CH:33]=[C:32]([CH2:34][CH:35]=O)[CH:31]=[CH:30][C:29]=1[O:37][CH3:38].[CH2:50]([NH:52][CH2:53][CH3:54])[CH3:51]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][C:23]([F:24])([F:26])[F:25])(=[O:12])=[O:13])[C:6](=[O:27])[C:5]2([N:39]1[CH2:48][C@H:47]([OH:49])[CH2:46][C@H:40]1[C:41]([N:43]([CH3:44])[CH3:45])=[O:42])[C:28]1[CH:33]=[C:32]([CH2:34][CH2:35][N:52]([CH2:53][CH3:54])[CH2:50][CH3:51])[CH:31]=[CH:30][C:29]=1[O:37][CH3:38]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 59867806HCID 59867806, compound

Product 1

HCID 59867874(4R)-1-(5-chloro-3-{5-[2-(diethylamino)ethyl]-2-methoxyphenyl}-1-{[4-methoxy-2-(trifluorome thoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinami de

Procedure

With 500 mg of the compound obtained in Example 219 and diethyl amine (0.16 ml) as starting materials, 180 mg of the title compound (light yellow amorphous) was obtained by a similar method to Example 220.

Sources & evidence

ORD record
ord-bcb58c5d8cc641bf99e21f2ef8c9fa0d
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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