2-(Chloromethyl)anisole → HCID 67428916, compound

HRID 1662769Notes

Reaction equation

HRID 1662769 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]Cl.[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16](=[O:21])[C:15]2=[O:22]>>[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16](=[O:21])[C:15]2([OH:22])[CH2:5][C:4]1[CH:7]=[CH:8][CH:9]=[CH:10][C:3]=1[O:2][CH3:1]

Participants

3

Reactant 2

HCID 814952-(Chloromethyl)anisoleHCID 872035-chloro-1H-indole-2,3-dione

Product 1

HCID 67428916HCID 67428916, compoundYield 30.2%

Procedure

With 4.50 g of 2-methoxybenzyl chloride and 4.34 g of 5-chloroisatin as starting materials, 2.19 g of the title compound (orange red solid) was obtained by a similar method to Step 21-1.

Sources & evidence

ORD record
ord-6bcdd8d37c974760b51c262f4829d655
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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