1-Bromo-2-fluorobenzene → HCID 67430175, compound

HRID 1662776Notes

Reaction equation

HRID 1662776 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].Br[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])[OH:12]

Participants

3

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 872035-chloro-1H-indole-2,3-dione

Product 1

HCID 67430175HCID 67430175, compoundYield 70.8%

Procedure

With 5.00 g of 5-chloroisatin and 6.92 g of 1-bromo-2-fluorobenzene as starting materials, 5.41 g of the title compound (yellow solid) was obtained by a similar method to Step 21-1.

Sources & evidence

ORD record
ord-bb9891ca690f4657a1c5555886794ec8
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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