5-chloro-1H-indole-2,3-dione → HCID 67429993, compound

HRID 1662780Notes

Reaction equation

HRID 1662780 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16](=[O:21])[C:15]2=[O:22]>>[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16](=[O:21])[C:15]2([C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10])[OH:22]

Participants

3

Reactant 2

HCID 872035-chloro-1H-indole-2,3-dioneHCID 1362922-Bromo-4-fluoroanisole

Product 1

HCID 67429993HCID 67429993, compoundYield 92.6%

Procedure

With 16.9 g of 2-bromo-4-fluoroanisol and 10.0 g of 5-chloroisatin as starting materials, 15.7 g of the title compound (yellow solid) was obtained by a similar method to Step 21-1.

Sources & evidence

ORD record
ord-db7192309c124406931e26daccbc2faf
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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