Trifluoroacetic acid → HCID 24960734, compound

HRID 1662852Notes

Reaction equation

HRID 1662852 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]3[N:29]=[CH:28][C:27]([NH:30][C:31](=[O:43])[C:32]4[CH:37]=[C:36]([NH:38][C:39](=[O:41])[CH3:40])[CH:35]=[CH:34][C:33]=4[Cl:42])=[CH:26][N:25]=3)=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:39]([NH:38][C:36]1[CH:35]=[CH:34][C:33]([Cl:42])=[C:32]([CH:37]=1)[C:31]([NH:30][C:27]1[CH:26]=[N:25][C:24]([NH:23][C:20]2[CH:19]=[CH:18][C:17]([S:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)(=[O:15])=[O:16])=[CH:22][CH:21]=2)=[N:29][CH:28]=1)=[O:43])(=[O:41])[CH3:40]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59652744HCID 59652744, compound

Product 1

HCID 24960734HCID 24960734, compoundYield 23.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of intermediate 58 (Example 112) (0.25 g, 0.40 mmol) in DCM (8 mL) was added TFA (30% in DCM, 6 mL) and the mixture stirred at room temperature for 2 h. The reaction mixture was concentrated and the residue purified by HPLC to afford the title compound (TFA salt; 50 mg, 23%) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue purified by HPLC

Sources & evidence

ORD record
ord-2b7a789318d2411397fb43107a71ff5e
Source dataset
uspto-grants-2011_10
Patent number
US08030487B2

Reaction notes

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