5-Chloro-4-nitrothiophene-2-sulfonyl chloride → HCID 86632423, compound

Participants

Reaction Steps

To a solution of 5-chloro-4-nitrothiophene-2-sulfonyl chloride (0.393 g, 1.5 mmol) in 15 mL of acetonitrile and 2 mL of water was added silver carbonate (0.414 g, 1.5 mmol) in portions in darkness. The resulting suspension was stirred overnight for 3 days, until no starting material is shown on the thin layer chromatography with an eluant of hexane/ethyl acetate (1:4). The mixture was filtered through half an inch of Celite® and the solid was washed with 3×15 mL acetonitrile. The organic filtrate was combined and organic solvent was removed via rotary evaporator to dryness and thus afforded 0.507 g of viscous solid with a yield of 96.4%. The resulting compound was not purified for further reactions. 1HNMR, d6-DMSO: 7.49 (d, 1H, 0.8 Hz)

Provenance & Evidence