反应详情

温度

20 °C

A suspension of 1.62 g (0.014 mol) of fumaric acid in 100 ml of acetone is brought to the boil. 100 ml of a toluene solution containing 10.77 g (0.028 mol) of pure quetiapine base is added to the boiling suspension, and the reaction mixture is heated to the boil for another 5 minutes. The precipitated crystalline product is cooled to approximately 20° C., and the reaction mixture is stirred for another 60 minutes. The precipitated crystalline quetiapine hemifumarate is filtered, washed, and dried.

1. additionis added to the boiling suspension
2. temperaturethe reaction mixture is heated to the boil for another 5 minutes
3. filtrationThe precipitated crystalline quetiapine hemifumarate is filtered
4. washwashed
5. customdried