Toluene → Quetiapine fumarate

Participants

Reaction Conditions

Reaction Steps

A suspension of 1.62 g (0.014 mol) of fumaric acid in 100 ml of acetone is brought to the boil. 100 ml of a toluene solution containing 10.77 g (0.028 mol) of pure quetiapine base is added to the boiling suspension, and the reaction mixture is heated to the boil for another 5 minutes. The precipitated crystalline product is cooled to approximately 20° C., and the reaction mixture is stirred for another 60 minutes. The precipitated crystalline quetiapine hemifumarate is filtered, washed, and dried.

Provenance & Evidence