Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Quetiapine | HCID 5002 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Quetiapine fumarate | HCID 5281025 | 185.7% |
Reaction Steps
0.8 g (0.007 mol) of fumaric acid is suspended in a solution of 30 ml of acetone and 0.3 ml of water. The suspension is brought to the boil, and 30 ml of a toluene solution containing 5.38 g (0.014 mol) of pure quetiapine base is added. The solution is refluxed for approximately 5 minutes, then cooled to a temperature of 0 to 5° C. and stirred at this temperature for 60 minutes. After being sucked off and dried, 5.7 g (0.013 mol) of quetiapine hemifumarate is obtained, i.e. 99.6% of the theory, having the HPLC purity 99.87%, and melting point 175.9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08034805B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-afdc2280458b4f0eb252942ba59419b2 |
|---|
| Source note | uspto-grants-2011_10 |
|---|
