HCID 10114725, compound → HCID 178436576, compound

HRID 1662999Notes

Reaction equation

HRID 1662999 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[CH2:28][CH3:29])[NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][C:17]2[CH:22]=[CH:21][N:20]=[C:19]([O:23]C)[CH:18]=2)=[N:8][N:7]=1>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[CH2:28][CH3:29])[NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][C:17]2[CH:22]=[CH:21][N:20]=[C:19]([OH:23])[CH:18]=2)=[N:8][N:7]=1

Participants

3

Reactant 1

HCID 10114725HCID 10114725, compound

Product 1

HCID 178436576HCID 178436576, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In analogy to Ex. 1, 500 mg (1.11 mMol) of 1-(3-bromo-4-ethyl-anilino)-4-[2-methoxy-(pyridin-4-yl)-methyl]-phthalazine in 12 ml of chloroform are reacted with 0.3 ml (2.2 mMol) Me3Sil to give the title compound: M.p. 251-252° C.; FAB-MS: (M+H)+=435/437; HPLC(Grad20-100) tRet=9.6.

Sources & evidence

ORD record
ord-708360d0e3db49f6950a55b899269807
Source dataset
uspto-grants-2011_10
Patent number
US08034814B2

Reaction notes

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