HCID 178448173, compound → HCID 178448172, compound

HRID 1663005Notes

Reaction equation

HRID 1663005 reaction equation
C(OC(=O)[NH:10][C@@H:11]1[CH2:16][O:15][C@@H:14]([CH:17]([CH3:19])[CH3:18])[O:13][CH2:12]1)C1C=CC=CC=1>CCOC(C)=O.[Pd]>[CH:17]([C@H:14]1[O:15][CH2:16][C@H:11]([NH2:10])[CH2:12][O:13]1)([CH3:19])[CH3:18]

Participants

4

Reactant 1

HCID 178448173HCID 178448173, compound

Product 1

HCID 178448172HCID 178448172, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Hydrogenation of 4.07 g (14.6 mMol) of trans-benzyl-(2-isopropyl-[1,3]dioxan-5-yl)-carbamate in 80 ml of EtOAc in the presence of 0.4 g of 10% Pd/C, followed by filtration through Celite and evaporation, yields the title compound: 1H NMR (CDCl3) δ 4.11 (m, 3H), 3.20 (t, 10.5 Hz, 2H), 3.04 (m, 1H), 1.80 (m, 1H), 1.56 (sb, H2N), 0.93 (d, 6H).

Sources & evidence

ORD record
ord-07afcc075b274272ae588ef2cf99bc36
Source dataset
uspto-grants-2011_10
Patent number
US08034814B2

Reaction notes

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