Thionyl Chloride → HCID 21096913, compound

HRID 1663026Notes

Reaction equation

HRID 1663026 reaction equation
S(Cl)([Cl:3])=O.[C:5]1([N:15]2[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22]O)[CH2:17][CH2:16]2)[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][N:6]=1>ClCCl>[Cl:3][CH2:22][CH2:21][CH:18]1[CH2:19][CH2:20][N:15]([C:5]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]=[CH:7][N:6]=2)[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21096914HCID 21096914, compound

Product 1

HCID 21096913HCID 21096913, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.20 ml (30.10 mmol) of thionyl chloride are added dropwise to a solution of 3.09 g (12.10 mmol) of 2-[1-(1-isoquinolyl)-4-piperidyl]ethanol, prepared in step 2.1, in 30 ml of dichloromethane. The reaction mixture is then refluxed for 5 hours.

Workup

  1. temperatureThe reaction mixture is then refluxed for 5 hours

Sources & evidence

ORD record
ord-e0dfc1e2180d4746b2b97d26068dc61c
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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