HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,3,3-Tetramethylguanidine → HCID 21096961, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| Reactant | 2,4-Oxazolidinedione | HCID 97389 | — |
| Reactant | HCID 21096920 | HCID 21096920 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 21096961 | HCID 21096961 | — |
Reaction Steps
A solution of 2.3 g (6.545 mmol) of 2-{1-[3-(trifluoromethyl)phenyl]-4-piperidyl}ethyl methanesulfonate, prepared in step 3.2, 0.694 g (6.87 mmol) of 1,3-oxazolidine-2,4-dione (J. Med. Chem., 1991, 34, 1538-1544) and 1.5 g (13.09 mmol) of 1,1,3,3-tetramethylguanidine in 30 ml of tetrahydrofuran is refluxed for 12 hours under an inert atmosphere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034818B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-d161078c802a44f9a753062da21681b9 |
| Source note | uspto-grants-2011_10 |