1,1,3,3-Tetramethylguanidine → HCID 21096961, compound

HRID 1663029Notes

Reaction equation

HRID 1663029 reaction equation
CS(O[CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[CH2:10][CH2:9]1)(=O)=O.[O:24]1[CH2:28][C:27](=[O:29])[NH:26][C:25]1=[O:30].CN(C)C(N(C)C)=N>O1CCCC1>[F:21][C:20]([F:23])([F:22])[C:16]1[CH:15]=[C:14]([N:11]2[CH2:12][CH2:13][CH:8]([CH2:7][CH2:6][N:26]3[C:27](=[O:29])[CH2:28][O:24][C:25]3=[O:30])[CH2:9][CH2:10]2)[CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 664601,1,3,3-TetramethylguanidineHCID 973892,4-OxazolidinedioneHCID 21096920HCID 21096920, compound

Product 1

HCID 21096961HCID 21096961, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2.3 g (6.545 mmol) of 2-{1-[3-(trifluoromethyl)phenyl]-4-piperidyl}ethyl methanesulfonate, prepared in step 3.2, 0.694 g (6.87 mmol) of 1,3-oxazolidine-2,4-dione (J. Med. Chem., 1991, 34, 1538-1544) and 1.5 g (13.09 mmol) of 1,1,3,3-tetramethylguanidine in 30 ml of tetrahydrofuran is refluxed for 12 hours under an inert atmosphere.

Workup

  1. temperatureis refluxed for 12 hours under an inert atmosphere

Sources & evidence

ORD record
ord-d161078c802a44f9a753062da21681b9
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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