Ammonia → HCID 66630125, compound

HRID 1663030Notes

Reaction equation

HRID 1663030 reaction equation
[NH3:1].[F:2][C:3]([F:26])([F:25])[C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][N:18]3[C:22](=[O:23])[CH2:21][O:20][C:19]3=[O:24])[CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1.O1CCCC1>CO>[F:25][C:3]([F:26])([F:2])[C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][NH:18][C:19](=[O:24])[O:20][CH2:21][C:22]([NH2:1])=[O:23])[CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 8028TetrahydrofuranHCID 21096961HCID 21096961, compound

Product 1

HCID 66630125HCID 66630125, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

9.3 ml (64.82 mmol) of a solution of aqueous ammonia (7N) in methanol are added to a solution of 0.77 g (2.16 mmol) of 3-(2-{1-[3-(trifluoromethyl)phenyl]-4-piperidyl}ethyl)-1,3-oxazolidine-2,4-dione, obtained in step 3.3, in 10 ml of a 1/1 mixture of methanol and tetrahydrofuran. Stirring is continued at room temperature for 24 hours.

Sources & evidence

ORD record
ord-d202411c58e64907b962fe10f1dea095
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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