4-Piperidineethanol → HCID 21096917, compound

HRID 1663044Notes

Reaction equation

HRID 1663044 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[NH:12]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][OH:20])[CH2:14][CH2:13]1>>[CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][OH:20])[CH2:14][CH2:13]2)[N:3]=1

Participants

3

Reactant 2

HCID 739534-PiperidineethanolHCID 6409683-Chloroisoquinoline

Product 1

HCID 21096917HCID 21096917, compoundYield 21.7%

Procedure

The process is performed as described in Example 4 (step 4.1). Starting with 1 g (6.11 mmol) of 3-chloroisoquinoline and 0.869 g (6.72 mmol) of 2-(4-piperidyl)ethanol, and after chromatography on silica gel, eluting with a 98/2 mixture of dichloromethane and methanol, 0.34 g of pure product is obtained in the form of an oil.

Workup

  1. washafter chromatography on silica gel, eluting with a 98/2 mixture of dichloromethane and methanol

Sources & evidence

ORD record
ord-501a1c6d3fc84cb0b71a28128fd641ce
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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