HCID 21096933, compound → HCID 21096934, compound

HRID 1663049Notes

Reaction equation

HRID 1663049 reaction equation
[Si]([O:18][CH2:19][CH2:20][C:21]1([F:37])[CH2:26][CH2:25][N:24]([C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[N:28]=2)[CH2:23][CH2:22]1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>O1CCCC1>[F:37][C:21]1([CH2:20][CH2:19][OH:18])[CH2:26][CH2:25][N:24]([C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[N:28]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 1

HCID 21096933HCID 21096933, compound

Product 1

HCID 21096934HCID 21096934, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.40 g (1.26 mmol) of n-tetrabutylammonium fluoride trihydrate is added to a solution of 2.15 g (4.19 mmol) of 2-[4-(2-{[tert-butyldiphenylsilyl]oxy}ethyl)-4-fluoro-1-piperidyl]quinoline, obtained in step 12.5, in 20 ml of tetrahydrofuran. Stirring is continued at room temperature for 4 hours. The mixture is concentrated to dryness and the residue obtained is then purified by chromatography on silica gel, eluting with a 35/65 and then 40/60 mixture of ethyl acetate and cyclohexane.

Workup

  1. concentrationThe mixture is concentrated to dryness
  2. customthe residue obtained
  3. customis then purified by chromatography on silica gel
  4. washeluting with a 35/65
  5. addition40/60 mixture of ethyl acetate and cyclohexane

Sources & evidence

ORD record
ord-f81487dbe9fd4e25b01adf71c17dc014
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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