2,6-Dibromopyridine → HCID 21096924, compound

HRID 1663051Notes

Reaction equation

HRID 1663051 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[NH:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][OH:17])[CH2:11][CH2:10]1>>[Br:8][C:4]1[N:3]=[C:2]([N:9]2[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][OH:17])[CH2:11][CH2:10]2)[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 122742,6-DibromopyridineHCID 739534-Piperidineethanol

Product 1

HCID 21096924HCID 21096924, compound

Procedure

The process is performed as described in Example 4 (step 4.1). Starting with 30.20 g (127 mmol) of 2,6-dibromopyridine and 16.45 g (127 mmol) of 2-(4-piperidyl)ethanol, and after chromatography on silica gel, eluting with a 30/70 mixture of ethyl acetate and cyclohexane, 7 g of pure product are obtained in the form of an oil.

Workup

  1. washafter chromatography on silica gel, eluting with a 30/70 mixture of ethyl acetate and cyclohexane, 7 g of pure product
  2. customare obtained in the form of an oil

Sources & evidence

ORD record
ord-002b61edcc064b00a0989c7075b7ae2a
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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