3-Azaisatoic anhydride → 1-(6-Oxo-1,6-dihydro-pyridin-3-ylmethyl)-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione

HRID 1663092Notes

Reaction equation

HRID 1663092 reaction equation
[NH:1]1[C:6]2[N:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:4](=[O:11])[O:3][C:2]1=[O:12].O[CH2:14][C:15]1[CH:16]=[CH:17][C:18](=[O:21])[NH:19][CH:20]=1>>[O:21]=[C:18]1[NH:19][CH:20]=[C:15]([CH2:14][N:1]2[C:6]3[N:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4](=[O:11])[O:3][C:2]2=[O:12])[CH:16]=[CH:17]1

Participants

3

Reactant 2

HCID 109865823-Azaisatoic anhydrideHCID 120185765-(hydroxymethyl)pyridin-2(1H)-one

Product 1

HCID 589899581-(6-Oxo-1,6-dihydro-pyridin-3-ylmethyl)-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione

Procedure

May be prepared by a similar procedure as described for preparation 7B, starting from 1H-pyrido[2,3-d][1,3]oxazine-2,4-dione (can be prepared as described by Beckwith and Hickman in J. Chem. Soc. (C), 1968 pp 2756-2759) and 5-hydroxymethyl-1H-pyridin-2-one (prepared as described in WO 01/77078 A1).

Workup

  1. customMay be prepared by a similar procedure

Sources & evidence

ORD record
ord-f9e3edd89e2045c4b4d748eb2a5376a0
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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