1-(Bromomethyl)-4-chlorobenzene → Hydroxylamine, O-((4-chlorophenyl)methyl)-, hydrochloride (1:1)

HRID 1663094Notes

Reaction equation

HRID 1663094 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.C(OC(=O)[NH:16][OH:17])(C)(C)C>>[ClH:1].[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][O:17][NH2:16])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 97534tert-butyl N-hydroxycarbamate

Product 1

HCID 217573Hydroxylamine, O-((4-chlorophenyl)methyl)-, hydrochloride (1:1)

Procedure

Same procedure as described for preparation 8. Starting materials: 4-Chlorobenzyl bromide and tert-butyl-N-hydroxycarbamate. 1H-NMR (DMSO-d6) δ 11.18 (bs, 3H), 7.44-7.51 (m, 4H), 5.06 (s, 2H).

Workup

  1. customSame procedure as described for preparation 8

Sources & evidence

ORD record
ord-f0aa96e7f1c54f958688e1a4e52b54dc
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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