5-Ethynyl-1-methyl-1H-imidazole → N-[3-(3-Methyl-3H-imidazol-4-ylethynyl)-benzyloxy]-2-[(pyridin-4-ylmethyl)-amino]-benzamide

HRID 1663135Notes

Reaction equation

HRID 1663135 reaction equation
I[C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][CH:26]=1)[CH2:5][O:6][NH:7][C:8](=[O:23])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][CH2:16][C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1.[C:27]([C:29]1[N:33]([CH3:34])[CH:32]=[N:31][CH:30]=1)#[CH:28]>>[CH3:34][N:33]1[C:29]([C:27]#[C:28][C:2]2[CH:3]=[C:4]([CH:24]=[CH:25][CH:26]=2)[CH2:5][O:6][NH:7][C:8](=[O:23])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][CH2:16][C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)=[CH:30][N:31]=[CH:32]1

Participants

3

Reactant 2

HCID 33331065-Ethynyl-1-methyl-1H-imidazoleHCID 58989772N-(3-Iodo-benzyloxy)-2-[(pyridin-4-ylmethyl)-amino]-benzamide

Product 1

HCID 11750954N-[3-(3-Methyl-3H-imidazol-4-ylethynyl)-benzyloxy]-2-[(pyridin-4-ylmethyl)-amino]-benzamide

Procedure

Starring materials: N-(3-Iodo-benzyloxy)-2-[(pyridin-4-ylmethyl)-amino]-benzamide (see Example 361) and 5-ethynyl-1-methyl-1-H-imidazole (Aldrich).

Sources & evidence

ORD record
ord-2a325dffa4d944ffabaccc9b08e02da8
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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