Morpholine, hydrochloride (1:1) → HCID 58989882, compound

HRID 1663141Notes

Reaction equation

HRID 1663141 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9]2[CH:28]=[CH:27][CH:26]=[CH:25][C:10]=2[C:11]([NH:13][O:14][CH2:15][C:16]2[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=2)[C:19](O)=[O:20])=[O:12])=[CH:3][CH:2]=1.Cl.[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[N:30]1([C:19]([C:18]2[CH:17]=[C:16]([CH:24]=[CH:23][CH:22]=2)[CH2:15][O:14][NH:13][C:11](=[O:12])[C:10]2[CH:25]=[CH:26][CH:27]=[CH:28][C:9]=2[NH:8][CH2:7][C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)=[O:20])[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 197884Morpholine, hydrochloride (1:1)HCID 58989917HCID 58989917, compound

Product 1

HCID 58989882HCID 58989882, compound

Procedure

Prepared by a similar procedure as described for preparation of example 405. Starting materials: 3-{2-[(Pyridin-4-ylmethyl)-amino]-benzoylaminooxymethyl}-benzoic acid (see example 403) and morpholine hydrochloride. 1H-NMR (DMSO-d6) δ 11.6 (bs, 1H), 8.49 (m, 2H), 7.89 (bt, 1H), 7.56 (m, 1H), 7.52-7.44 (m, 2H), 7.42-7.34 (m, 2H), 7.31 (m, 2H), 7.19 (m, 1H), 6.58-6.49 (m, 2H), 4.98 (s, 2H), 4.47 (d, 2H), 3.80-3.10 (m, 8H).

Workup

  1. customPrepared by a similar procedure
  2. customas described for preparation of example 405

Sources & evidence

ORD record
ord-b040d87c574a4dd69f7990b4ab5444a9
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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