1-Methylpiperazine → HCID 58989819, compound

HRID 1663143Notes

Reaction equation

HRID 1663143 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9]2[CH:28]=[CH:27][CH:26]=[CH:25][C:10]=2[C:11]([NH:13][O:14][CH2:15][C:16]2[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=2)=[O:12])=[CH:3][CH:2]=1.[CH3:29][N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH3:29][N:30]1[CH2:35][CH2:34][N:33]([C:20]([C:19]2[CH:18]=[CH:17][C:16]([CH2:15][O:14][NH:13][C:11](=[O:12])[C:10]3[CH:25]=[CH:26][CH:27]=[CH:28][C:9]=3[NH:8][CH2:7][C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)=[CH:24][CH:23]=2)=[O:21])[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 58989803HCID 58989803, compound

Product 1

HCID 58989819HCID 58989819, compound

Procedure

Prepared by a similar procedure as described for preparation of example 405. Starting materials: 4-{2-[(Pyridin-4-ylmethyl)-amino]-benzoylaminooxymethyl}-benzoic acid (see example 404) and 1-methylpiperazine. The title compound was crystallised from toluene. 13C-NMR (DMSO-d6) δ 168.6, 167.2, 149.5, 148.9, 148.2, 137.3, 135.7, 132.4, 128.7, 128.0, 126.8, 121.9, 114.8, 113.3, 111.4, 76.4, 54.4, 46.8, 45.5, 44.8.

Workup

  1. customPrepared by a similar procedure
  2. customas described for preparation of example 405
  3. customThe title compound was crystallised from toluene

Sources & evidence

ORD record
ord-1cda71bc90f64c0fb8028134a318dc7a
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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