(4-Methoxyphenyl)boronic acid → N-(4'-Methoxy-biphenyl-2-ylmethoxy)-2-[(pyridin-4-ylmethyl)-amino]-benzamide

HRID 1663147Notes

Reaction equation

HRID 1663147 reaction equation
I[C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][O:5][NH:6][C:7](=[O:22])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][CH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1.[CH3:27][O:28][C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1>>[CH3:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([C:2]2[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=2[CH2:4][O:5][NH:6][C:7](=[O:22])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][CH2:15][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 11487973N-((2-iodobenzyl)oxy)-2-((pyridin-4-ylmethyl)amino)benzamide

Product 1

HCID 58989860N-(4'-Methoxy-biphenyl-2-ylmethoxy)-2-[(pyridin-4-ylmethyl)-amino]-benzamide

Procedure

Prepared by a similar procedure as described for preparation of example 363. Starting materials: N-(2-Iodo-benzyloxy)-2-[(pyridin-4-ylmethyl)amino]-benzamide (see example 360) and 4-methoxyphenylboronic acid (Aldrich).

Workup

  1. customPrepared by a similar procedure
  2. customas described for preparation of example 363

Sources & evidence

ORD record
ord-1466a15495f245c19186f636b22ee473
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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