Hydrochloric Acid → HCID 67436189, compound

HRID 1663233Notes

Reaction equation

HRID 1663233 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:13][CH2:12]1)(C)(C)C.[ClH:24]>O1CCOCC1.C(OCC)C>[ClH:24].[ClH:24].[ClH:24].[N:17]1([CH:14]2[CH2:15][CH2:16][N:11]([CH2:10][CH2:9][CH2:8][NH2:7])[CH2:12][CH2:13]2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67435611HCID 67435611, compound

Product 1

HCID 67436189HCID 67436189, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent2×

Procedure

A mixture of (3-[1,4′]bipiperidinyl-1′-yl-propyl)-carbamic acid tert-butyl ester (2.15 g, 6.6 mmol), dry dioxane (40 mL) and 6.5 N hydrogen chloride in dioxane (22 mL) was stirred at room temperature overnight, then diluted with diethyl ether and stirred at 0° C. for 1 h. The precipitated crystals were filtered off, washed with diethyl ether and dried to yield 2.03 g (92%) of the title compound as a beige solid.

Workup

  1. stirringstirred at 0° C. for 1 h
  2. filtrationThe precipitated crystals were filtered off
  3. washwashed with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-dc801b9f5855447ab231f1cf354aa76e
Source dataset
uspto-grants-2011_10
Patent number
US08034827B2

Reaction notes

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