Ethyl cyanoacetate → Ethyl 2-aminothiophene-3-carboxylate

HRID 1663272Notes

Reaction equation

N[C:2]1[S:3]C=C[C:6]=1C#N.[CH3:9][CH2:10][O:11][C:12]([CH2:14][C:15]#[N:16])=[O:13]>>[NH2:16][C:15]1[S:3][CH:2]=[CH:6][C:14]=1[C:12]([O:11][CH2:10][CH3:9])=[O:13]

Participants

Reactant 2

HCID 7764Ethyl cyanoacetate

HCID 7366072-Aminothiophene-3-carbonitrile

Product 1

HCID 1988156Ethyl 2-aminothiophene-3-carboxylate

Procedure

The same procedure as 2-aminothiophene-3-carbonitrile was used except replacing malononitrile with ethyl cyano acetate. 1H-NMR (CDCl3, 400 MHz): 6.95, 6.15, 4.26, 1.32.

Sources & evidence

ORD record: ord-ac8cab2f37b44f0188cf1777e6b2c6d2
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08034895B2

Reaction notes

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