Hydrazine hydrate (1:1) → HCID 24851119, compound

HRID 1663319Notes

Reaction equation

HRID 1663319 reaction equation
[C:1]([C:4]1[N:8]=[CH:7][NH:6][C:5]=1[C:9]#[N:10])(=O)[CH3:2].O.[NH2:12][NH2:13]>C(O)C>[NH2:10][C:9]1[N:13]=[N:12][C:1]([CH3:2])=[C:4]2[N:8]=[CH:7][NH:6][C:5]=12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178467459HCID 178467459, compound

Product 1

HCID 24851119HCID 24851119, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2.00 g 5-acetyl-3H-imidazole-4-carbonitrile and 4.00 ml hydrazine hydrate in 50 ml of ethanol is heated to 100° C., until the reaction is complete according to HPLC-MS. After cooling to ambient temperature the reaction mixture is evaporated down, stirred with 20 ml of cold ethanol and suction filtered. The filter cake is washed with diethyl ether and dried.

Workup

  1. temperatureAfter cooling to ambient temperature the reaction mixture
  2. customis evaporated down
  3. filtrationfiltered
  4. washThe filter cake is washed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-8dc94e1876b142a3968a7b6757b20664
Source dataset
uspto-grants-2011_10
Patent number
US08034941B2

Reaction notes

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