Nitric Acid → 3-Bromo-4-hydroxy-5-nitrobenzaldehyde

HRID 1663366Notes

Reaction equation

HRID 1663366 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].[N+:11]([O-])([OH:13])=[O:12]>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10])[CH:5]=[O:6]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 763083-Bromo-4-hydroxybenzaldehyde

Product 1

HCID 14943783-Bromo-4-hydroxy-5-nitrobenzaldehyde

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a cooled solution of 3-bromo-4-hydroxybenzaldehyde (5 g) in acetic acid (50 ml) was added nitric acid (1.17 ml). The mixture was allowed to reach room temperature. After stirring for 17 h, the resulting precipitate was filtered off. The solid was washed with water and dried in vacuo.

Workup

  1. customto reach room temperature
  2. filtrationthe resulting precipitate was filtered off
  3. washThe solid was washed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-7621a148482142bf87e49eebabbd5208
Source dataset
uspto-grants-2011_10
Patent number
US08034945B2

Reaction notes

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