Benzyl Bromide → HCID 58558319, compound

HRID 1663472Notes

Reaction equation

HRID 1663472 reaction equation
[NH2:1][C:2]1[C:3]([C:7]2[N:11]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:10](=[O:19])[O:9][N:8]=2)=[N:4][O:5][N:6]=1.[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:12]([N:11]1[C:10](=[O:19])[O:9][N:8]=[C:7]1[C:3]1[C:2]([NH:1][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[N:6][O:5][N:4]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 7498Benzyl Bromide2×HCID 674354223-(4-amino-1,2,5-oxadiazol-3-yl)-4-benzyl-1,2,4-oxadiazol-5(4H)-one

Product 1

HCID 58558319HCID 58558319, compoundYield 15%

Procedure

A solution of 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-benzyl-1,2,4-oxadiazol-5(4H)-one (60.0 mg, 0.231 mmol) and benzyl bromide (28 μL, 0.23 mmol) was heated at 150° C. for 5 h. Additional benzyl bromide (28 μL) was added to the incomplete reaction and heating was continued for another 16 h. Purification of the crude reaction mixture by preparative HPLC gave the desired product (12 mg, 15%). LCMS for C18H16N5O3 (M+H)+: m/z=349.9.

Workup

  1. temperatureheating
  2. customPurification of the crude
  3. customreaction mixture by preparative HPLC

Sources & evidence

ORD record
ord-2463beb9373c4ec4b0a7b35ea414b0db
Source dataset
uspto-grants-2011_10
Patent number
US08034953B2

Reaction notes

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