反应详情

温度

2.5 °C

A solution of (2,6-dimethylphenyl)-methanesulfonyl chloride (452 g, 2.07 mol) and acetone (2.0 L) was added over 90 m to cooled (0-5° C.), stirred, concentrated ammonium hydroxide (28%, 900 mL, 227 g NH3, 13.3 mol). The reaction mixture was maintained <10° C. during the addition. The reaction mixture was allowed to warm to room temperature and was stirred for 1 h. Water (2.0 L) was added to the reaction mixture and it was stirred for 1 h at 0-5° C. The white solid was collected by filtration, washed with cold water (2×1 L), and vacuum dried to give 349 g (85%) of (2,6-dimethylphenyl)-methanesulfonamide with 99% purity (as determined by HPLC).

1. temperatureThe reaction mixture was maintained <10° C. during the addition
2. temperatureto warm to room temperature
3. stirringwas stirred for 1 h
4. stirringwas stirred for 1 h at 0-5° C
5. filtrationThe white solid was collected by filtration
6. washwashed with cold water (2×1 L), and vacuum
7. customdried