HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyryl chloride → N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | 6-Iodoimidazo[1,2-B]pyridazin-2-amine | HCID 57441024 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)-2-methylpropanamide | HCID 57441028 | 73.2% |
Reaction Steps
Using 6-iodoimidazo[1,2-b]pyridazin-2-amine (1.0 g, 3.85 mmol), N,N-dimethylacetamide (8.0 mL) and isobutyryl chloride (0.44 mL, 4.23 mmol) as starting materials and in the same manner as in Reference Example 5, the title compound (0.93 g, 73%) was obtained as a dark brown powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08034812B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-22dd16d209ee48b18093102838ba5f97 |
| Source note | uspto-grants-2011_10 |