Isobutyryl chloride → N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)-2-methylpropanamide

HRID 1663627Notes

Reaction equation

HRID 1663627 reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH2:11])[N:10]=2)[N:7]=1.[C:12](Cl)(=[O:16])[CH:13]([CH3:15])[CH3:14]>CN(C)C(=O)C>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12](=[O:16])[CH:13]([CH3:15])[CH3:14])[N:10]=2)[N:7]=1

Participants

4

Reactant 2

HCID 62325Isobutyryl chlorideHCID 574410246-Iodoimidazo[1,2-B]pyridazin-2-amine

Product 1

HCID 57441028N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)-2-methylpropanamideYield 73.2%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Using 6-iodoimidazo[1,2-b]pyridazin-2-amine (1.0 g, 3.85 mmol), N,N-dimethylacetamide (8.0 mL) and isobutyryl chloride (0.44 mL, 4.23 mmol) as starting materials and in the same manner as in Reference Example 5, the title compound (0.93 g, 73%) was obtained as a dark brown powder.

Sources & evidence

ORD record
ord-22dd16d209ee48b18093102838ba5f97
Source dataset
uspto-grants-2011_10
Patent number
US08034812B2

Reaction notes

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