Dimethylacetamide → HCID 57505441, compound

HRID 1663678Notes

Reaction equation

HRID 1663678 reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH2:11])[N:10]=2)[N:7]=1.[O:12]1[CH2:17][CH2:16][CH:15]([C:18](Cl)=[O:19])[CH2:14][CH2:13]1.CN(C)C(=O)C>O>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:18]([CH:15]3[CH2:16][CH2:17][O:12][CH2:13][CH2:14]3)=[O:19])[N:10]=2)[N:7]=1

Participants

5

Reactant 3

HCID 31374DimethylacetamideHCID 2795505Oxane-4-carbonyl chlorideHCID 574410246-Iodoimidazo[1,2-B]pyridazin-2-amine

Product 1

HCID 57505441HCID 57505441, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 6-iodoimidazo[1,2-b]pyridazin-2-amine (550 mg, 2.11 mmol), tetrahydro-2H-pyran-4-carbonyl chloride (320 mg, 2.15 mmol) and N,N-dimethylacetamide (5.0 mL) was stirred at room temperature for 3 hr. The reaction mixture was poured into water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)tetrahydro-2H-pyran-4-carboxamide as a white powder.

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. washwashed with water
  3. customair-dried

Sources & evidence

ORD record
ord-380a520095144a84b487ca2adf670dbb
Source dataset
uspto-grants-2011_10
Patent number
US08034812B2

Reaction notes

Loading…