Pyrazinecarbonyl chloride → HCID 57505569, compound

HRID 1663831Notes

Reaction equation

HRID 1663831 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[F:24])[O:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([NH:15][C:16]([CH:18]3[CH2:20][CH2:19]3)=[O:17])[N:14]=2)[N:11]=1.[N:25]1[CH:30]=[CH:29][N:28]=[CH:27][C:26]=1[C:31](Cl)=[O:32]>CN(C)C(=O)C>[CH:18]1([C:16]([NH:15][C:13]2[N:14]=[C:9]3[CH:8]=[CH:7][C:6]([O:5][C:4]4[CH:21]=[CH:22][C:23]([F:24])=[C:2]([NH:1][C:31]([C:26]5[CH:27]=[N:28][CH:29]=[CH:30][N:25]=5)=[O:32])[CH:3]=4)=[N:11][N:10]3[CH:12]=2)=[O:17])[CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 88279Pyrazinecarbonyl chlorideHCID 57505446N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Product 1

HCID 57505569HCID 57505569, compoundYield 26.1%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Using a solution of N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (327 mg, 1.0 mmol) and 2-pyrazinecarbonylchloride (171 mg, 1.2 mmol) in N,N-dimethylacetamide (6.0 mL), and by a reaction in the same manner as in Example 148, the title compound (113 mg, 26%) was obtained as colorless crystals.

Workup

  1. customby a reaction in the same manner as in Example 148

Sources & evidence

ORD record
ord-6093270ce08a4b7886124e97961bd445
Source dataset
uspto-grants-2011_10
Patent number
US08034812B2

Reaction notes

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