反应详情

To a solution of N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]acetamide (5.6 g, 18.6 mmol) in N,N-dimethylacetamide (44.8 mL) was added 1,3-dimethyl-1H-pyrazole-5-carbonyl chloride (3.25 g, 20.4 mmol). After stirring at room temperature for 2 hr, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate/tetrahydrofuran, washed with saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate/ethanol to give the title compound (6.1 g, 78%) as a white powder.

1. extractionthe mixture was extracted with ethyl acetate/tetrahydrofuran
2. washwashed with saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltrated
5. customThe solvent was evaporated under reduced pressure
6. washthe residue was washed with ethyl acetate/ethanol