Triethylamine → (-)-Epibatidine-L-tartrate

HRID 1664117Notes

Reaction equation

HRID 1664117 reaction equation
[CH2:1]1[CH:6]2[NH:7][CH:3]([CH:4]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[N:10][CH:9]=3)[CH2:5]2)[CH2:2]1.Cl.Cl.C(N(CC)CC)C>ClCCl>[CH:13]1[C:8]([CH:4]2[CH:3]3[NH:7][CH:6]([CH2:1][CH2:2]3)[CH2:5]2)=[CH:9][N:10]=[C:11]([Cl:14])[CH:12]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 21946437(+)-Epibatidine dihydrochloride

Product 1

HCID 1204(-)-Epibatidine-L-tartrate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(+)—Epibatidine dihydrochloride was treated with triethyl amine (10 eq) in dichloromethane for 1 hour at room temperature and epibatidine was then isolated following standard isolation protocol.

Sources & evidence

ORD record
ord-d15268b317ba47b99b96431e94718745
Source dataset
uspto-grants-2011_10
Patent number
US08039459B2

Reaction notes

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