Trifluoroacetic acid → HCID 131726181, compound

HRID 1664186Notes

Reaction equation

HRID 1664186 reaction equation
[CH3:1][O:2][P:3]([C:7]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:8]=1[CH2:9][NH:10]C(=O)OC(C)(C)C)([O:5][CH3:6])=[O:4].[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[NH2:10][CH2:9][C:8]1[CH:18]=[CH:19][C:20]([F:22])=[CH:21][C:7]=1[P:3](=[O:4])([O:5][CH3:6])[O:2][CH3:1]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58777338HCID 58777338, compound

Product 1

HCID 131726181HCID 131726181, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

A solution of tert-butyl 2-(dimethoxyphosphoryl)-4-fluorobenzylcarbamate (0.140 g, 0.42 mmol) in dichloromethane (5 ml) was treated with trifluoroacetic acid (5 ml) and the resulting mixture was stirred at 25° C. for 1 h. The solvent was then evaporated in vacuo to give the title amine salt as an amorphous white solid. MS (ESI+) m/z 234 [M+H+].

Workup

  1. customThe solvent was then evaporated in vacuo

Sources & evidence

ORD record
ord-695c61779b644b53993e0f75e268d29d
Source dataset
uspto-grants-2011_10
Patent number
US08039458B2

Reaction notes

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