HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 5-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester | HCID 67439609 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester | HCID 86626579 | — |
Reaction Steps
A mixture of 29.7 g (95.1 mmol) of N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester in 300 ml of THF and 300 ml of 2N HCl is stirred overnight. Ethyl acetate is added, and the mixture is washed twice with brine. The organic phase is dried over sodium sulfate and evaporated to yield the product in the form of a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039455B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-1612f793da6a4beda7e6ce3a5b6b8e03 |
| Source note | uspto-grants-2011_10 |