反应详情

A mixture of 10.3 g (47.2 mmol) of 3-amino-5-oxazol-2-yl-benzoic acid methyl ester, 25 g of anhydrous sodium carbonate and 7.69 ml (51.9 mmol) of benzyl chloroformate is stirred for 16 h at rt and filtered. The filtrate is concentrated, and the residue is chromatographed on silica gel (EtOAc/hexane 1:2) to yield the product in the form of colorless crystals.

1. filtrationfiltered
2. concentrationThe filtrate is concentrated
3. customthe residue is chromatographed on silica gel (EtOAc/hexane 1:2)
4. customto yield the product in the form of colorless crystals