反应详情

温度

25 °C

A solution of 1.08 g 2-(acetyl-allyl-amino)-6-chloro-isonicotinic acid ethyl ester (3.82 mmol) in 15 ml MeOH is treated with 5.5 ml 1N NaOH (5.5 mmol) and stirred at 25° C. for 30 min. The reaction is quenched with 6 ml 1 N HCl and with EtOAc extracted. Crystallization from a small amount of EtOAc gives the title compound as yellow crystals.

1. customThe reaction is quenched with 6 ml 1 N HCl and with EtOAc
2. extractionextracted
3. customCrystallization from a small amount of EtOAc