HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1664219Generated: November 3, 2026
Sodium Hydroxide → 2-(Acetyl-allyl-amino)-6-chloro-isonicotinic acid
https://huagongshe.com/reaction/1664219
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(Acetyl-allyl-amino)-6-chloroisonicotinic acid ethyl ester | HCID 86620483 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Acetyl-allyl-amino)-6-chloro-isonicotinic acid | HCID 86620480 | — |
Reaction Steps
A solution of 1.08 g 2-(acetyl-allyl-amino)-6-chloro-isonicotinic acid ethyl ester (3.82 mmol) in 15 ml MeOH is treated with 5.5 ml 1N NaOH (5.5 mmol) and stirred at 25° C. for 30 min. The reaction is quenched with 6 ml 1 N HCl and with EtOAc extracted. Crystallization from a small amount of EtOAc gives the title compound as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08039455B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-bd171766e5c24c22ba2b44e2d5d30cb3 |
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| Source note | uspto-grants-2011_10 |
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