HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitro-5-(2-oxopyrrolidin-1-yl)benzoic acid → 3-Amino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitro-5-(2-oxopyrrolidin-1-yl)benzoic acid | HCID 22253023 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 3-Amino-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid | HCID 22252990 | — |
Reaction Steps
To the solution of 2.19 g (8.75 mmol) 3-nitro-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid in 50 ml MeOH/THF 3/2 are added 0.2 g Pd/C (10% Engelhard 4505) and the reaction is stirred at rt under hydrogen (1 atm) for 18 h. After filtration through celite the solvent is evaporated at reduced pressure to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039455B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-0e77f158f8904d6cbd034c05dad5cc1d |
| Source note | uspto-grants-2011_10 |