Trifluoroacetic acid → HCID 25062252, compound

HRID 1664530Notes

Reaction equation

HRID 1664530 reaction equation
COC1C=CC(C[N:8]2[C:16]3[C:15](=[O:17])[N:14]4[C:18]([CH3:21])=[N:19][N:20]=[C:13]4[N:12]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:11]=3[N:10]=[C:9]2[C:27]2[S:28][CH:29]=[CH:30][N:31]=2)=CC=1.FC(F)(F)C(O)=O>>[CH3:21][C:18]1[N:14]2[C:15](=[O:17])[C:16]3[NH:8][C:9]([C:27]4[S:28][CH:29]=[CH:30][N:31]=4)=[N:10][C:11]=3[N:12]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:13]2=[N:20][N:19]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57600258HCID 57600258, compound

Product 1

HCID 25062252HCID 25062252, compound

Conditions

Temperature
55 °C

Procedure

The mixture of 6-(4-methoxybenzyl)-3-methyl-9-pentyl-7-(1,3-thiazol-2-yl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one (100 mg, 0.22 mmol) in trifluoroacetic acid (5 mL, 65 mmol) was stirred at 55° C. overnight. The reaction solution was concentrated and purified using preparative LCMS to yield the desired product. LCMS calculated for C15H18N7OS: 344.1. found: 344.1.

Workup

  1. concentrationThe reaction solution was concentrated
  2. custompurified

Sources & evidence

ORD record
ord-e396e93c1db44289ad9af200464c6beb
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

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